| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 21/01/25 18:45 | AS Monaco | Aston Villa | 1:0 |
| 21/01/25 18:45 | Atalanta Bergamo | SK Sturm Graz | 5:0 |
| 21/01/25 21:00 | Liverpool FC | OSC Lille | 2:1 |
| 21/01/25 21:00 | Club Atlético de Madrid | Bayer Leverkusen | 2:1 |
| 21/01/25 21:00 | Club Brujas | Juventus de Turin | 0:0 |
| 21/01/25 21:00 | Estrella Roja Belgrado | PSV Eindhoven | 2:3 |
| 21/01/25 21:00 | SK Slovan Bratislava | VfB Stuttgart | 1:3 |
| 21/01/25 21:00 | FC Bologna | Borussia Dortmund | 2:1 |
| 21/01/25 21:00 | Benfica Lisboa | F. C. Barcelona | 4:5 |
| 22/01/25 18:45 | Shaktar Donetsk | Stade Brest 29 | -:- |
| 22/01/25 18:45 | RB Leipzig | Sporting de Portugal | -:- |
| 22/01/25 21:00 | Arsenal FC | Dinamo Zagreb | -:- |
| 22/01/25 21:00 | AC Milán | Girona F. C. | -:- |
| 22/01/25 21:00 | Real Madrid C. F. | FC Red Bull Salzburgo | -:- |
| 22/01/25 21:00 | Paris St. Germain | Manchester City | -:- |
| 22/01/25 21:00 | Celtic Glasgow | Young Boys Berna | -:- |
| 22/01/25 21:00 | Feyenoord Rotterdam | FC Bayern de Múnich | -:- |
| 22/01/25 21:00 | Sparta Praga | Inter de Milán | -:- |